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Specifically, an arginine has been substituted for a glutamic acid at the third position, and it has a 13-amino acid extension peptide added to its N-terminus

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The results paved the way for liraglutide, branded as Saxenda, to be approved in the US as a once-a-day subcutaneous injection in December 2014 and in Europe in 2015 for the treatment of chronic weight management combined with a reduced calorie diet and increased physical exercise (Molteni, Chen)

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