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and gluconeogenesis is suppressed 38 in part due to depletion of pyruvate and lactate 39

The advantages of diabetes control during pregnancy, however, may exceed the dangers

Standard dosing protocols begin at 2.5 mg per week (as a titration dose) and escalate in 2.5 mg increments up to 15 mg per week, with each increase separated by at least four weeks

A summary of endocrine influences on the hypothalamicpituitarygonadal axis is shown in Figure 1