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Appendix Abbreviations ACTH adrenocorticotropic hormone AMH anti-Mllerian hormone BMI body mass index BP blood pressure COCPs combined oral contraception pills CPA cyproterone acetate DHEA dehydroepiandrosterone DHEA-S dehydroepiandrosterone sulfate DHT dihydrotestosterone EE ethinylestradiol FAI free androgen index FBG fasting blood glucose FDA Food and Drug Administration FN1 fibronectin 1 FSH follicular stimulating hormone FT free testosterone GIP glucose-dependent insulinotropic polypeptide GLP-1 glucagon-like peptide-1 GLP-1RA glucagon-like peptide-1 receptor agonist GLP-1RAs glucagon-like peptide-1 receptor agonists GnRH gonadotropin-releasing hormone HbA1c hemoglobin A1c HDL high-density lipoprotein HOMA-IR homeostatic model assessment of insulin resistance HPA hypothalamic-pituitary-adrenal HPG hypothalamic-pituitary-gonadal IL interleukin IR insulin resistance IVF in vitro fertilization LH luteinizing hormone MetS metabolic syndrome MR-proADM mid-regional pro-adrenomedullin MR-proANP mid-regional pro-atrial natriuretic peptide NAFLD nonalcoholic fatty liver disease OCPs oral contraception pills OGTT oral glucose tolerance test PCOS polycystic ovarian syndrome PIIINP procollagen type 3 amino-terminal peptide PRDX6 peroxiredoxin 6 RAAS renin-angiotensin-aldosterone system RCT randomized control trial ROS reactive oxygen species SHBG sex hormone-binding globulin T2DM type 2 diabetes mellitus TC total cholesterol TG triglycerides TNF- tumor necrosis factor-alpha TZDs thiazolidinediones WC waist circumference WHR waist-to-hip ratio Footnotes ORCID iDs: Bassel H

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GLP-1 medications are prescription therapeutics that are not controlled substances and are not included in standard drug screening panels, including those outlined in the Substance Abuse and Mental Health Services Administration (SAMHSA) guidelines for federal workplace drug testing

Surgical Interventions: Some patients who experience Ozempic Face may require surgical intervention to address extreme volume loss and skin laxity