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For many people, this is a short-lived phenomenon that often lasts just seconds or minutes and is due to harmless reasons, such as a sudden shift in blood flow when standing up or after being exposed to loud noises

Calcitonin has a strong hypocalcaemic effect via inhibition of osteoclasts ( Figure 1 ) (79) and promotion of renal excretion of calcium, presumably by inhibiting tubular reabsorption of calcium (79)

When the two are combined, the resulting effect is a clear state of mental alertness derived from the caffeine, but without the jitters, thanks to the calming effect of L-theanine