At around 500mg/day, they are rarely reported, but as intake approaches 1,000mg/day or higher, gastrointestinal complaints become more likely.67 In one study, about 6% of patients at 1,000mg/day experienced GI issues, and a few discontinued the trial as a result.43 Still, research suggests these digestive side effects are often temporary, fading as the body adapts, especially when people start with smaller doses and build up gradually.37 67 Long-term use The best safety data come from ALS studies, where patients took 2,000mg/day (1g twice daily) for up to 18 months.38 42 Roughly 20% experienced gastrointestinal side effects, but most were able to continue by lowering their dose.67 Longer exposure has not been systematically studied, so the safety of multi-year supplementation remains unknown
MEDICUBE Code MECUS05-GTR Gross Weight 199g (0.44 lbs) Milky dual-layer toner for 24-hour radiant glass-skin glow Product Benefit Glutathione brightens and hydrates for glass-skin radiance Skin Type Fit normaldrycombinationsensitive Texture & Feel LightweightFast-AbsorbingDewy FinishSmooth Application AI-generated from the product information
Enhances Nutrient Absorption: Ideal for individuals with digestive issues that limit B12 absorption from food
The synthetic version used in research maintains the same amino acid sequence and biological activity as the naturally occurring fragment
