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This dual role, stimulating both synthesis and controlled degradation, is characteristic of wound healing rather than simple collagen accumulation

Kidney Int 35:865870 Hirschberg RR, Kopple JD (1988) Increase in renal plasma flow and glomerular filtration rate during growth hormone treatment may be mediated by insulin-like growth factor I

PMID: 18492208

Once absorbed, it triggers several biological actions relevant to skin health: Stimulation of collagen synthesis : Upregulates collagen I and III production Elastin production and glycosaminoglycan support : Promotes sulfated glycosaminoglycan synthesis Matrix regulation : Balances MMPs and TIMPs to maintain connective tissue integrity Growth factor upregulation : Increases growth factors such as VEGF, BDNF, and BMP-2, which are crucial for wound healing and tissue regeneration Antioxidant and anti-inflammatory activity : Demonstrates GHK-Cu's ability to act as an antioxidant and anti-inflammatory agent by neutralizing reactive oxygen species (ROS), modulating inflammatory markers, and protecting skin cells from environmental damage The peptides origin as a collagen fragment released after tissue injury explains its role as a natural signal peptide for repair and tissue remodeling