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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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For some patients, this can also affect nutrient absorption, which is crucial for eye health. This brings us to the importance of considering the full range of effects GLP-1 medications can have on patient health, particularly in managing chronic conditions such as diabetic retinopathy

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