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A real-world observational study found that people living with obesity reported a reduction in emotional eating and cravings over 3 months of receiving semaglutide [13], and in a qualitative interview-based study of people receiving weight loss medication, participants reported reductions in food noise [14]

Recent studies have also demonstrated that exendin-4 is mediated by Ca 2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/prolactin regulatory element binding (CaMKK/CaMKIV/PREB) pathway increases liver ABCA1 expression and reduces cholesterol accumulation [71]

Have ongoing symptoms that may require medical evaluation, lab testing, or primary care follow-up

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