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Future research should prioritize the identification of actionable targets within the ferroptotic pathway, assess the regulatory potential of natural compounds and traditional medicines on iron metabolism, and accelerate translational efforts to incorporate ferroptosis-modulating strategies into clinical practice (Table 1)

The body can produce glycine naturally from other amino acids and it can also be consumed through the diet by eating protein-rich foods such as meat, fish, beans, peas, lentils or dairy, or by taking supplements

8% hit plateau before week 36 then maintained successfully

Probiotics, prebiotics, and synbiotics are under clinical investigation as adjunct therapies to modulate gut-brain interactions and reduce systemic inflammation (Chan et al., 2022