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5.1 Toward functional synergy: The Importance of a synbiotic approach in the cardiovascular context The concept of synbiotics, as redefined by the International Scientific Association for Probiotics and Prebiotics (ISAPP), refers to a mixture of living microorganisms (probiotics) and substrates selectively used by host microorganisms (prebiotics) that confer a health benefit to the host [106]

Evidence of a hepatoprotective effect also exists for exenatide: this drug has been evaluated in several randomized clinical studies involving T2DM and obese patients and was shown to reduce liver enzymes, hepatic fat content, hepatic triglyceride content, and epicardial fat [78,79,80]