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FIGURE 1 Estrogens play a multifaceted role in the central nervous system (CNS), influencing synaptic plasticity, neuronal development, and survival in newly formed spinal synapses, as well as promoting neural stem cell proliferation and maintaining the integrity of the blood-brain barrier ( Preclinical and human studies have shown that ER is abundantly expressed in the hypothalamus, particularly in the preoptic area (POA), ventromedial nuclei (VMN), amygdala, and periventricular nuclei (PV)

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There were no significant between-group differences in GM, WM and CFS content (Table 2)