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Oral semaglutide (Rybelsus) requires specific administration instructions: it must be taken on an empty stomach before the first food, beverage, or other oral medications of the day, with no more than 4 ounces of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications

Interestingly, unlike other trials with TNF inhibitors, concomitant use of methotrexate appeared to produce greater protection from structural progression in this study