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Graphical abstract Access this article Similar content being viewed by others Data availability The data generated during the current study are available from the corresponding author upon reasonable request

57 GSH depletion occurred without a change in GSSG, suggesting efflux of GSH out of the glia, perhaps with additional increased conversion of GSH to GSSG in response to increased hydrogen peroxide formation

This observation supports the hypothesis that ferroptosis, a type of nonapoptotic cell death, has a greater possibility of inducing inflammation than apoptosis

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