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Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease

An alteration from an indolent to a metastatic state may be stimulated by HFD-induced lipid accumulation in prostate tumors, the mechanism of which may be related to the sterol regulatory element-binding protein (SREBP)-related prometastatic lipogenic program

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It also serves as a required substrate for two important families of enzymes: the sirtuins, which help regulate healthy cellular aging, and the PARPs, which help repair damaged DNA