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From a mean baseline body weight of 96 kg after randomization, there was a mean reduction of 0.3 kg in the patients who received insulin detemir add-on therapy compared to a mean reduction of 1.1 kg in the patients who continued on unchanged treatment with liraglutide injection 1.8 mg + metformin alone

Importantly, weight loss from semaglutide is primarily fat loss (not water or muscle), making it metabolically superior to restrictive dieting

Intramuscular injection typically produces sharper, more intense pain during injection, followed by prolonged soreness at the site lasting several days

The onset of action for L-Lysine HCl can vary from person to person