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So, Secher asked, does that mean that these are the only regions that are activated by GLP-1 receptor agonists? She and her team do not believe that this is the case, she said, because when you have interaction with one neuron, this can communicate to many other neurons in deeper layers of the brain. To test whether that was happening, her team used c-Fos, a protein that can be used as a marker for neuronal activation

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In a study targeting suicide attempts as the endpoint, a control group with a higher prevalence of depression and suicidal ideation might lead to outcome bias, as evidenced by the increased incidence of suicidal ideation within the control group