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Nor does the application disclose a synergistic effect, such as by administering a sub-therapeutic dose of each agent, which nonetheless results in a desired therapeutic result

But the agency is a little hamstrung: if there is evidence that a drug is useful for the purpose being advertised, even if the drug isnt FDA-approved for that purpose, the FTC wont act, Sklar says

As our understanding of HFpEF evolves, GLP-1RAs have the potential to become a cornerstone of therapy, addressing the multifactorial nature of this condition and improving outcomes in a challenging patient population