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This rebound effect is a practical reality and part of the decision whether to start a medication that requires long-term use or to explore oral paths that might be used differently

And the benefit is much better than whatever we were doing before. Its getting on toward late afternoon, and Asprey makes himself an espresso

It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes

This is because animal studies showed that the drugs can cause a specific kind of thyroid tumor, though that link hasnt been found in any studies on humans