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Milkweed species in the genus Asclepias are optimal candidates to investigate cardiac glycoside biosynthesis due to tremendous variation among species

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The research established CJC-1295 as the first clinically viable long-acting GHRH analog and demonstrated its potential for once-weekly or less frequent dosing in GH replacement research protocols

Because there were seven randomized trials reporting on more than 500 patients from which to draw evidence (including five trials that compared PPS to placebo, one trial that examined PPS dose-response effects, and one that compared PPS to CyA), the numerous observational studies on PPS were not used