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Because synthetic GLP-1 doesn't break down as easily as the real thing, it can "help create the feeling that you just ate dinner, so you don't want more food," according to Weill Cornell Medicine obesity expert Louis Aronne, MD, whose most recent research on the drugs appeared in the Journal of the American Medical Association in November 2024

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5.2 Tirzepatide (SURMOUNT Trials) Tirzepatide demonstrated even greater mean weight loss in SURMOUNT trials. Findings included: Weight reductions exceeding 20% in some cohorts Dose-dependent gastrointestinal symptoms Lean mass reduction proportional to total weight loss Again, detailed micronutrient panels were not central trial endpoints