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They modified the structure of small opioid neuropeptides that possessed very weak GH-releasing activity, assuming that structural alteration might produce new peptides with greater efficacy

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Ther Adv Neurol Disord 16:17562864231193530 Li Y, Ye Z, Lai W, Rao J, Huang W, Zhang X, Yao Z, Lou T (2017) Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury