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The temperature applied in this study was initially reduced at a programmed rate of 5C/min from 4C to 10C, then at a programmed rate of 40C/min from 10 to 100C and finally at a programmed rate of 20C/min from 100 to 140C

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Firstly, it stimulates insulin secretion from pancreatic beta cells, but crucially, this effect is glucose-dependent meaning insulin is only released when blood glucose levels are elevated

When the drug is not on the shortage list, a compounded drug can only be produced for a patient-specific prescription