We did not compare other biomarkers of oxidative stress or anti-oxidant potential with E h Cys/CySS and E h GSH/GSSG, such as levels of ascorbic acid, 4-hydroxynonenal, malondialdehyde, F2-isoprostanes, or enzymatic activity of common redox enzymes such as superoxide dismutase, glutathione peroxiredoxin, or thioredoxin
The most frequently reported treatment-emergent adverse events included nausea, diarrhea and vomiting, most of them reported as mild or moderate and occurred during the dose titration period
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This means clinical evidence for Type 1 patients comes from smaller studies, real-world observations, and case series rather than large pivotal trials