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In reproductive tissues, peptides may impact follicle development, ovarian signaling, and local inflammation, all of which are important for fertility

Furthermore, the GSH-responsive nanocarriers can be designed by (i) conjugating the drug molecule with polymer or other molecules via disulfide bond and then self-assembled into nanomaterial or lipidosomes [75]

Finally, while pharmacological tolerance might be considered, there is no established evidence linking prolonged tirzepatide use with reduced efficacy

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