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Upon sensing environmental stress or cellular damage, the absent in melanoma 2 inflammasome (AIM2) and NLR family pyrin domain-containing 3 (NLRP3) inflammasome assemble and recruit the inflammasome adapter protein apoptosis-associated speck-like protein containing CARD, leading to the activation of pro-inflammatory caspases [137]

Interestingly, the sensation of caffeine bitterness was directly associated with messenger ribonucleic acid (mRNA) levels of several T2Rs in human taste papillae and caffeine intake in humans [104]

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