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Nevertheless, iron overload has been demonstrated to promote the progression of ALD via inducing oxidative stress, triggering ferroptosis of hepatocytes, and promoting the activation of KCs and HSCs

doi: 10.14336/AD.2023.0904 106 YanS.HanZ.WangT.WangA.LiuF.YuS.et al

The finding was further supported by c-met-binding experiments, in which HGF was pre-treated with GSSSG and LASSS at the same molar ratio 1:4000 at which the satellite-cell activation index was rescued to a level comparable to that of non-nitrated regular HGF, as shown in Figure 1d, followed by exposure to peroxynitrite (1:2000) and evaluated for c-met-binding by a sandwich ELISA-like assay on recombinant c-met-Fc chimera (Figure 1e, left column