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GLP-1 drugs, for example, target brain neurons in the hindbrain involved in appetite control

Most users report seeing noticeable improvements in 6 to 12 weeks of consistent use with a visible reduction in pigmentation patches, overall brightness, and improved skin texture

This means orforglipron can be taken in pill form to achieve similar effects, including weight loss and other improvements in metabolic health, like better blood sugar control, lower blood pressure, and reduced cholesterol

In some cases, healthcare providers may consider short-term prescription antiemetics, with attention to potential QT interval prolongation risk and electrolyte abnormalities