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[DOI] [PubMed] [Google Scholar] 221.Todd BJ

MALE FERTILITY AND SPERMATOGENESIS Hypogonadotropic Hypogonadism: Steroidogenesis Restoration Serum testosterone: increase from 200 ng/dL above baseline Primary failure: no response (Leydig cell damage) Secondary failure: present response but low baseline Applications: Differentiation between primary and secondary hypogonadism Pre-pubertal Leydig cell reserve evaluation Treatment response prediction 5

Non-glycaemic effects T2DM and sarcopenia share a number of pathophysiological processes, and current evidence suggests that they may all be reciprocally causal