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Signs of degradation in lyophilized retatrutide include: color change from white to yellow or brown, collapse or liquefaction of the lyophilized cake, unusual odor upon opening the vial, and failure to dissolve clearly during reconstitution

It makes sense to try reducing the dose and monitor weight closely

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In the heart, validated studies find the receptor concentrated in the sinoatrial node, which explains the modest increase in heart rate, and in atrial myocytes, where it stimulates the release of atrial natriuretic peptide