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Clinical Trials of topical JAK inhibitor Ruxolitinib cream met the primary endpoint in both pivotal phases 3 clinical trials with critical secondary endpoints, with a significantly higher proportion of the trial group achieving at least 75% improvement in the F-VASI score (a quantitative measure to assess skin symptoms in patients with vitiligo) relative to baseline than the placebo group at week 24 of treatment (118)

Scientific references involving CJC-1295 (no DAC) frequently address growth hormonereleasing hormone (GHRH) receptor-associated signaling pathways, while Ipamorelin is examined in the context of ghrelin receptor (GHS-R) interaction modeling

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