It depends on the concentration you want
However, the SAPNets are based on understandable descriptors (e.g., size, shape, aspect-ratio, and type of coating) and do not require additional computational calculations, allows consideration in environmental influence (such as solvent and pH), and the users can easily see how the change of the descriptor values will influence the predicted toxicity
However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists
You can train hard, follow a perfect program, and dial in your nutrition but if your body can't repair itself efficiently, you'll hit a wall in performance and risk injury