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The B12 in supplements is synthesised in laboratories using fermented bacterial cultures which are refined and added to capsules, liquids and patches available over the counter

The two pathways don't overlap, which means research designs can probe both vascular and cytoskeletal mechanisms simultaneously without confounding mechanism-specific effects

The argument can be made that large scientific studies are expensive, and no company is going to spend the money to conduct these studies on natural supplements for which a patent cannot be obtained

This piece is about which one is, and why the answer matters beyond a single peptide