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This gap partly stems from the traditional reliance on larval models for speed, leaving adult zebrafish underutilized for studies of chronic exposure, cumulative toxicity, and long-term therapeutic efficacy (Choi T

4 Discussion A population PK model of oral semaglutide was developed and validated in the current study and found suitable for accurately describing the PK properties across demographic covariates and dosing conditions and for simulating PK profiles in subjects dosed with oral semaglutide

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