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Because tirzepatide activates the GIP receptor in addition to the GLP-1 receptor that semaglutide targets, it produces a broader metabolic effect, including stronger appetite suppression, improved insulin sensitivity, and enhanced fat oxidation

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Dosing for compounded semaglutide is typically the same as dosing for FDA-approved versions of semaglutidebut with varying higher doses, as Ozempic and Wegovy have slightly different higher doses