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The expression level and activity of SP1 are often abnormally elevated in lung cancer tissues, and its high expression is significantly associated with a poor prognosis ( 2.7.2 Naamidine J inhibits the nuclear translocation of SP1 by targeting CSE1L to slow down lung injury Naamidine J (NJ) is a marine alkaloid and has been identified as a specific inhibitor of the nuclear transport protein CSE1L through chemical proteomics technology