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10.1038/npp.2016.281 99 PriegoT.Ibanez De CaceresI.MartinA

Its rapid degradation by proteolytic enzymes in circulation leads to a short half-life, typically necessitating pulsatile administration to mimic natural hormone rhythms and maintain physiological effectiveness

Researchers from one study said: We found IGF-I levels to be significantly associated with the performances (controlled for education) on the Digit Symbol Substitution test and the Concept Shifting Task, which measure perceptual-motor and mental processing speed

Erichsen, L