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This article examines the evidence, eligibility, expected outcomes, and safety considerations for GLP-1 therapy

doi:10.1530/eje.0.1510483

It may also not be appropriate for people with certain gastrointestinal conditions, a history of pancreatitis, or those who are pregnant or planning to become pregnant

However, rapid weight loss may lead to: Facial volume loss including loss of fat that supports youthful contours Reduced dermal density increasing lines, wrinkles, and sagging Muscle mass reduction decreased facial muscle support Bone density loss possible long-term changes to facial structure These changes can accelerate visible aging, but they are not irreversible