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The identification of TfR1 in the hemopexin interactome affinity isolations from extracts of HL-60 cells, together with our ICC data from HL-60 cells and also from HepG2 cells, both support and extend our previous studies, published in 1990, showing that HPX travels through HepG2 cells together with the Tf/TfR1 pathway via its clathrin-dependent pathway for endocytosis (Smith and Hunt, 1990)