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Several studies have demonstrated the therapeutic benefit of a ketogenic diet for recovery in adult rodent TBI models as well as in pediatric mice, which rely on ketone metabolism at baseline [95]

Figure 3 below summarizes these processes, highlighting the interplay between bacterial infection, immune mediators (e.g., TNF-, IL-6, transforming growth factor-beta [TGF-], IL-10), and cellular actors (e.g., neutrophils, M1/M2 macrophages, fibroblasts, keratinocytes, endothelial cells) during wound healing [43, 48]