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Moreover, other specialized mitochondria-residing proteins, such as the apoptosis inducing factor (AIF) and endonuclease G, are translocated to the nuclei following their release from mitochondria and promote peripheral chromatin condensation and high molecular weight DNA fragmentation

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Genetic susceptibility plays a foundational role, with shared polymorphisms and risk locisuch as MALAT1, ALDH2, and JMJD3implicated in both vascular and oncogenic pathways