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They tend to show up as a general daily drag: things that are easy to attribute to stress, aging, or just a rough stretch

In the subsequent sections, we will discuss how the immunomodulatory effects discussed here impact different organs and diseases, highlighting the potential for dopaminergic immunomodulation in the treatment of a wide array of pathogenic conditions

10.12659/AJCR.925020 Am J Case Rep

Therefore, it is important to understand the pathophysiology that leads to the loss of dopaminergic neurons, along with reliable biomarkers that may help distinguish PD from other conditions, monitor its progression, or indicate a positive response to a therapeutic intervention