Although previous studies showed a lack of therapeutic benefit for GIP agonists, current studies show that the glucose lowering and weight loss effects of tirzepatide are at least as effective as GLP-1 RAs with a similar adverse effect profile
More gym sessions and tighter dieting often make things worse, the same reason training volume after 40 becomes counterproductive faster than expected
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However, significant weight loss and glycemic control become evident after 8-12 weeks of consistent use, and the full effect is seen after 6 months or more