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Further investigations are needed to elucidate the specific mis-spliced genes and proteins directly influenced by SF3B1 mutations together with the crosstalk between SF3B1 and MAPK pathway in tumorigenesis of MM, and the findings may provide a new perspective for targeted therapy
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For instance, cyanidin-3-O-glucoside (C3G), an anthocyanin in berries, reduces body weight and improves metabolic homeostasis in mice by altering hepatic FGF21 14
Unlike injectable formulations that typically require cold-chain storage, oral GLP-1RAs bypass refrigeration constraints, thereby reducing manufacturing and distribution costs and improving accessibility in resource-limited settings [73]
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