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Sequencing libraries were generated using NEBNext UltraTM RNA Library Prep Kit for Illumina (NEB) following manufacturers recommendations and index codes were added to attribute sequences to each sample

While GLP-1 receptor agonists are licensed in the UK for: Body mass index (BMI) of 30 kg/m or above, or BMI of 27 kg/m or above with weight-related comorbidities (such as type 2 diabetes or hypertension) It's important to note that NHS-funded access is more restricted, following NICE technology appraisals

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However, treatment with WR-1065, Enoxacin, and Doripenem restored secretion to control levels (Fig