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References (this section): Eli Lilly: notes GI side effects commonly reported and often during dose escalation (Phase 2 summary) NEJM (2023): safety/adverse events in Phase 2 publication Is retatrutide FDA approved

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doi: 10.1016/j.xcrm.2025.102214

Semaglutide reduces body weight by around 14% on average, while tirzepatide in clinical trials has shown up to 20% weight loss on average