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In animal models, homozygous deletion of IGF-1 or IGF-1R genes results in high lethality and severe CNS deficits, including reduced brain size and loss of specific neurons, highlighting the essential role of IGF-1 signaling in neurodevelopment ( 2.7 Endothelial function and vascular health HGH is directly involved in maintaining vascular health, primarily through stimulating nitric oxide (NO) production, a short-lived gas considered an essential vasodilator

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Fletcher MM, Keov P, Truong TT, Mennen G, Hick CA, Zhao P, et al

[PubMed] [Elsevier] Scholz RW, Graham KS, Gumpricht E, Reddy CC