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When used for type 2 diabetes, the dosing recommendations are: Immediate-release tablet: 500 mg once or twice daily, or 850 mg once daily Extended-release tablet: 500 mg1,000 mg once daily For weight loss, PCOS, gestational diabetes, or other off-label uses of metformin, the dosage varies but most people start at 500 mg

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Despite the convenience of oral administration, subcutaneous versions are, and will remain, fundamentally more efficacious than their oral counterparts, and their production will be more cost-efficient due to significantly lower API requirements