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To overcome the limitations of these redox potential measurements, genetically encoded biosensors have been developed, including redox-sensitive green fluorescent protein (roGFP) and yellow fluorescent protein (YFP) [30], [31], which enable non-invasive and dynamic redox measurements in vivo

Pathway-level genetic context is the upstream variable underneath every protocol choice

In cancer, inducers of ferroptosis, such as erastin and RSL3, take advantage of the high levels of iron and PUFAs in tumor cells [94, 95], while inhibitors like fer-1 and liproxstatin-1 show potential in treating neurodegenerative diseases, including Alzheimers, where lipid peroxidation contributes to neuronal damage [96]

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