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Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases

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Daidzein (DAI), a soy isoflavone with anti-inflammatory and antioxidant effects, alleviates oxidative stress and hepatocyte apoptosis in concanavalin A-induced liver injury by activating the SIRT1/AMPK pathway, increasing LC3-positive expression and Beclin-1 and LC3-II/LC3-I protein levels, enhancing autophagy, regulating lipid metabolism, and reducing hepatocyte apoptosis in NAFLD rats (Li et al., 2021

Because it can pass across lipid membranes, it may be able to let organelles know how the cell is doing [48]