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Hyperprolactinemia interferes with the activity of gonadotropin-releasing hormone (GnRH) neurons and is a recognized cause of functional hypogonadism ( At the central level, excessive prolactin inhibits the synthesis and pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH), thereby reducing the release of pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone, ultimately leading to hypogonadism ( In women, prolactin has a significant inhibitory effect on ovarian steroid production, leading to reduced synthesis and secretion of estradiol and progesterone (59)

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According to GEN (Genetic Engineering & Biotechnology News), here are the Top 10 #CDMOs of 2025, ranked by 2024 revenues